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(Publications by the original Chan lab, and by the Comai lab and collaborators)
(Publications on CENH3 and haploid induction by the original Chan lab, by the Comai lab and collaborators)
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===Publications on CENH3 and haploid induction by the original Chan lab, by the Comai lab and collaborators===
 
===Publications on CENH3 and haploid induction by the original Chan lab, by the Comai lab and collaborators===
  
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===Funding===
 
===Funding===
 
This research is funded by the Howard Hughes Medical Institute and the Gordon and Betty Moore Foundation through Grant GBMF3068 (Chan research).
 
This research is funded by the Howard Hughes Medical Institute and the Gordon and Betty Moore Foundation through Grant GBMF3068 (Chan research).

Revision as of 16:29, 19 May 2015

Contents

The role of CENH3 in centromere function

Following a close collaboration with the Chan lab and the demise of Simon Chan in the Summer of 2012, we have assimilated Chan lab researchers working on different aspects of centromeric function and its epigenetic determination. We are investigating the structural features, evolutionary constraints, and mechanisms that determine the interaction of centromeric histone H3 (CENH3) with the centromere and its instability in outcrosses resulting in parent-specific genome elimination. In collaboration with the Korf lab, we are investigating the mechanisms of extreme chromosome fragmentation and reassembly that are associated to chromosome elimination.

Mohan Marimuthu

Mohan studies the early molecular events that lead to genome elimination in the zygote and early embryo resulting from crosses between centromere-compromised individuals and wild type.

Shamoni Maheshwari

Shamoni studies the mechanisms behind rapid evolution of CENH3 and centromeric repeats.

Han Tan

Han Tan, collaborates with Keith Bradnam, Ian Korf, to understand how certain chromosomes become highly rearranged in crosses between centromere-compromised individuals and wild type.

Collaborators

Research aimed at applying the haploid induction system to cassava and banana, funded by BREAD, is continuing in the laboratory of Anne Britt at UCD.

Simon Chan

1974-2012

Simon chan 1.png

Simon started the CENH3 project when he joined UCD in 2006. His laboratory achieved a lot in the 6 years that followed. It has been a pleasure and a privilege to have been his friends and have worked with Simon. We miss him. Tributes to Simon Chan: Genome Biology, Department of Plant Biology

Publications on CENH3 and haploid induction by the original Chan lab, by the Comai lab and collaborators

[1][2][3][4][5][6][7][8][9][10][11][12]

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  7. Cite error: Invalid <ref> tag; no text was provided for refs named PMID:21813763
  8. Cite error: Invalid <ref> tag; no text was provided for refs named PMID:21695238
  9. Cite error: Invalid <ref> tag; no text was provided for refs named PMID:21330535
  10. Cite error: Invalid <ref> tag; no text was provided for refs named PMID:20933291
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  12. Cite error: Invalid <ref> tag; no text was provided for refs named PMID:20336146

Funding

This research is funded by the Howard Hughes Medical Institute and the Gordon and Betty Moore Foundation through Grant GBMF3068 (Chan research).

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