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(Simon Chan)
(Funding)
 
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==The role of CENH3 in centromere function==
 
==The role of CENH3 in centromere function==
Following a close collaboration with the Chan lab and the demise of Simon Chan in the Summer of 2012, we have assimilated Chan lab researchers working on different aspects of centromeric function and its epigenetic determination. We are investigating the structural features, evolutionary constraints, and mechanisms that determine the interaction of centromeric histone H3 (CENH3) with the centromere and its instability in outcrosses resulting in parent-specific genome elimination. In collaboration with the Korf lab, we are investigating the mechanisms of extreme chromosome fragmentation and reassembly that are associated to chromosome elimination.  
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Following a close collaboration with the Chan lab and the demise of Simon Chan in the Summer of 2012, we have assimilated Chan lab researchers working on different aspects of centromeric function and its epigenetic determination. We are investigating the structural features, evolutionary constraints, and mechanisms that determine the interaction of centromeric histone H3 (CENH3) with the centromere and its instability in outcrosses resulting in parent-specific genome elimination. We are investigating the mechanisms of extreme chromosome fragmentation and reassembly that are associated to chromosome elimination.  
 
===Mohan Marimuthu===
 
===Mohan Marimuthu===
 
Mohan studies the early molecular events that lead to genome elimination in the zygote and early embryo resulting from crosses between centromere-compromised individuals and wild type.
 
Mohan studies the early molecular events that lead to genome elimination in the zygote and early embryo resulting from crosses between centromere-compromised individuals and wild type.
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===Shamoni Maheshwari===
 
===Shamoni Maheshwari===
 
Shamoni studies the mechanisms behind rapid evolution of CENH3 and centromeric repeats.
 
Shamoni studies the mechanisms behind rapid evolution of CENH3 and centromeric repeats.
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===Jessica Rodrigues===
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Jessica Rodrigues (and the folks above) is studying processes that determine the efficiency of genome elimination. This work is part of a multinational project awarded to Anna Kultunow at CSIRO. We collaborate with Andreas Houben (IPK, Germany), Anna Kultunow (CSIRO), and other labs.
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===Xiaoya Song===
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Xiaoya Song is working with Jessica Rodrigues in our Capture Heterosis project. She is also working in the Chetelat lab (UCD) with Shamoni to understand the effect of variation in CENH3 within the genus Solanum on genome elimination.
  
 
===Collaborators===
 
===Collaborators===
Han Tan, currently hosted in the Neil Hunter laboratory, collaborates with Keith Bradnam, Ian Korf, and the Comai lab to understand how certain chromosomes become highly rearranged in crosses between centromere-compromised individuals and wild type. Research aimed at applying the haploid induction system to cassava and banana, funded by BREAD, is continuing in the laboratory of Anne Britt at UCD.
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Research aimed at applying the haploid induction system to cassava and banana, funded by BREAD, is continuing in the [http://www.plb.ucdavis.edu/labs/britt/Welcome.html laboratory of Anne Britt at UCD]. The effect of CENH3 variation in the Solanum genus on genome elimination is being studied in collaboration with the laboratory of Roger Chetelat.  
  
 
===Simon Chan===
 
===Simon Chan===
[[image:simon_chan_1.png|200px|]]
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1974-2012
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[[image:simon_chan_1.png|300px|]]
  
 
Simon started the CENH3 project when he joined UCD in 2006. His laboratory achieved a lot in the 6 years that followed. It has been a pleasure and a privilege to have been his friends and have worked with Simon. We miss him. Tributes to Simon Chan: [http://genomebiology.com/2013/14/1/103 Genome Biology], [http://www.plb.ucdavis.edu/labs/srchan/ Department of Plant Biology]
 
Simon started the CENH3 project when he joined UCD in 2006. His laboratory achieved a lot in the 6 years that followed. It has been a pleasure and a privilege to have been his friends and have worked with Simon. We miss him. Tributes to Simon Chan: [http://genomebiology.com/2013/14/1/103 Genome Biology], [http://www.plb.ucdavis.edu/labs/srchan/ Department of Plant Biology]
  
===Publications by the Chan lab===
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===Publications on CENH3 and haploid induction by the original Chan lab, by the Comai lab and collaborators===
  
<ref name=PMID:23363705/><ref name=PMID:22766638/><ref name=PMID:21813763/><ref name=PMID:21695238/><ref name=PMID:21330535/><ref name=PMID:20933291/><ref name=PMID:20628040/><ref name=PMID:20336146/>
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<ref name=PMID:25977984/><ref name=PMID:25622028/><ref name=PMID:25358957/><ref name=PMID:24915001/><ref name=PMID:23363705/><ref name=PMID:22766638/><ref name=PMID:21813763/><ref name=PMID:21695238/><ref name=PMID:21330535/><ref name=PMID:20933291/><ref name=PMID:20628040/><ref name=PMID:20336146/>
 
<references/>
 
<references/>
  
 
===Funding===
 
===Funding===
This research is funded by the Howard Hughes Medical Institute and the Gordon and Betty Moore Foundation through Grant GBMF3068 (Chan research).
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This research is funded by a sub-award from CSIRO for the grant Captured Heterosis from the Bill and Melinda Gates Foundation, and by industry. It has been previously funded by the Howard Hughes Medical Institute and the Gordon and Betty Moore Foundation through Grant GBMF3068 (Chan research).

Latest revision as of 20:56, 16 May 2017

Contents

[edit] The role of CENH3 in centromere function

Following a close collaboration with the Chan lab and the demise of Simon Chan in the Summer of 2012, we have assimilated Chan lab researchers working on different aspects of centromeric function and its epigenetic determination. We are investigating the structural features, evolutionary constraints, and mechanisms that determine the interaction of centromeric histone H3 (CENH3) with the centromere and its instability in outcrosses resulting in parent-specific genome elimination. We are investigating the mechanisms of extreme chromosome fragmentation and reassembly that are associated to chromosome elimination.

[edit] Mohan Marimuthu

Mohan studies the early molecular events that lead to genome elimination in the zygote and early embryo resulting from crosses between centromere-compromised individuals and wild type.

[edit] Shamoni Maheshwari

Shamoni studies the mechanisms behind rapid evolution of CENH3 and centromeric repeats.

[edit] Jessica Rodrigues

Jessica Rodrigues (and the folks above) is studying processes that determine the efficiency of genome elimination. This work is part of a multinational project awarded to Anna Kultunow at CSIRO. We collaborate with Andreas Houben (IPK, Germany), Anna Kultunow (CSIRO), and other labs.

[edit] Xiaoya Song

Xiaoya Song is working with Jessica Rodrigues in our Capture Heterosis project. She is also working in the Chetelat lab (UCD) with Shamoni to understand the effect of variation in CENH3 within the genus Solanum on genome elimination.

[edit] Collaborators

Research aimed at applying the haploid induction system to cassava and banana, funded by BREAD, is continuing in the laboratory of Anne Britt at UCD. The effect of CENH3 variation in the Solanum genus on genome elimination is being studied in collaboration with the laboratory of Roger Chetelat.

[edit] Simon Chan

1974-2012

Simon chan 1.png

Simon started the CENH3 project when he joined UCD in 2006. His laboratory achieved a lot in the 6 years that followed. It has been a pleasure and a privilege to have been his friends and have worked with Simon. We miss him. Tributes to Simon Chan: Genome Biology, Department of Plant Biology

[edit] Publications on CENH3 and haploid induction by the original Chan lab, by the Comai lab and collaborators

[1][2][3][4][5][6][7][8][9][10][11][12]

  1. Cite error: Invalid <ref> tag; no text was provided for refs named PMID:25977984
  2. Cite error: Invalid <ref> tag; no text was provided for refs named PMID:25622028
  3. Cite error: Invalid <ref> tag; no text was provided for refs named PMID:25358957
  4. Cite error: Invalid <ref> tag; no text was provided for refs named PMID:24915001
  5. Cite error: Invalid <ref> tag; no text was provided for refs named PMID:23363705
  6. Cite error: Invalid <ref> tag; no text was provided for refs named PMID:22766638
  7. Cite error: Invalid <ref> tag; no text was provided for refs named PMID:21813763
  8. Cite error: Invalid <ref> tag; no text was provided for refs named PMID:21695238
  9. Cite error: Invalid <ref> tag; no text was provided for refs named PMID:21330535
  10. Cite error: Invalid <ref> tag; no text was provided for refs named PMID:20933291
  11. Cite error: Invalid <ref> tag; no text was provided for refs named PMID:20628040
  12. Cite error: Invalid <ref> tag; no text was provided for refs named PMID:20336146

[edit] Funding

This research is funded by a sub-award from CSIRO for the grant Captured Heterosis from the Bill and Melinda Gates Foundation, and by industry. It has been previously funded by the Howard Hughes Medical Institute and the Gordon and Betty Moore Foundation through Grant GBMF3068 (Chan research).

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