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The role of CENH3 in centromere function

Following a close collaboration with the Chan lab and the demise of Simon Chan in the Summer of 2012, we have assimilated Chan lab researchers working on different aspects of centromeric function and its epigenetic determination. We are investigating the structural features, evolutionary constraints, and mechanisms that determine the interaction of centromeric histone H3 (CENH3) with the centromere and its instability in outcrosses resulting in parent-specific genome elimination. In collaboration with the Korf lab, we are investigating the mechanisms of extreme chromosome fragmentation and reassembly that are associated to chromosome elimination.

Mohan Marimuthu

Mohan studies the early molecular events that lead to genome elimination in the zygote and early embryo resulting from crosses between centromere-compromised individuals and wild type.

Shamoni Maheshwari

Shamoni studies the mechanisms behind rapid evolution of CENH3 and centromeric repeats.


Han Tan, currently hosted in the Neil Hunter laboratory, collaborates with Keith Bradnam, Ian Korf, and the Comai lab to understand how certain chromosomes become highly rearranged in crosses between centromere-compromised individuals and wild type.

Simon Chan

Simon chan 1.png Tributes to Simon Chan: Genome Biology, [ Department of Plant Biology]


This research is funded by the Howard Hughes Medical Institute and the Gordon and Betty Moore Foundation through Grant GBMF3068 (Chan research).

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